一种与严重急性呼吸综合征相关的新型冠状病毒的特征

Characterization of a novel coronavirus associated with severe acute respiratory syndrome.

作者信息

Rota Paul A, Oberste M Steven, Monroe Stephan S, Nix W Allan, Campagnoli Ray, Icenogle Joseph P, Peñaranda Silvia, Bankamp Bettina, Maher Kaija, Chen Min-Hsin, Tong Suxiong, Tamin Azaibi, Lowe Luis, Frace Michael, DeRisi Joseph L, Chen Qi, Wang David, Erdman Dean D, Peret Teresa C T, Burns Cara, Ksiazek Thomas G, Rollin Pierre E, Sanchez Anthony, Liffick Stephanie, Holloway Brian, Limor Josef, McCaustland Karen, Olsen-Rasmussen Melissa, Fouchier Ron, Günther Stephan, Osterhaus Albert D M E, Drosten Christian, Pallansch Mark A, Anderson Larry J, Bellini William J

机构信息

National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.

出版信息

Science. 2003 May 30;300(5624):1394-9. doi: 10.1126/science.1085952. Epub 2003 May 1.

DOI:10.1126/science.1085952

PMID:12730500

Abstract

In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.

摘要

2003年3月，发现一种新型冠状病毒（SARS-CoV）与严重急性呼吸综合征（SARS）病例有关。本报告确定了SARS-CoV完整基因组的序列，并对病毒基因组进行了初步表征。SARS-CoV基因组长度为29727个核苷酸，有11个开放阅读框，其基因组结构与其他冠状病毒相似。系统发育分析和序列比较表明，SARS-CoV与先前已鉴定的任何冠状病毒均无密切关系。