Dalton Catherine M, Brex Peter A, Miszkiel Katherine A, Fernando Kryshani, MacManus David G, Plant Gordon T, Thompson Alan J, Miller David H
NMR Research Unit, Institute of Neurology, National Hospital for Neurology and Neurosurgery, United Kingdom.
Ann Neurol. 2003 May;53(5):673-6. doi: 10.1002/ana.10580.
In clinically isolated syndromes, the new McDonald criteria for multiple sclerosis diagnosis require new gadolinium-enhancing lesions for dissemination in time at a 3-month follow-up magnetic resonance imaging scan. In a cohort of 56 patients, these criteria were specific (95%) but less sensitive (58%) for clinically definite multiple sclerosis at 3 years. If new T2 lesions were allowed as an alternative for dissemination in time, sensitivity increased (74%) with maintained specificity (92%), enabling an accurate diagnosis of multiple sclerosis in more patients.
在临床孤立综合征中，用于多发性硬化症诊断的新麦克唐纳标准要求在3个月的随访磁共振成像扫描中出现新的钆增强病变以证明时间上的播散。在一个56例患者的队列中，这些标准在3年时对临床确诊的多发性硬化症具有特异性（95%）但敏感性较低（58%）。如果允许将新的T2病变作为时间上播散的替代指标，则敏感性增加（74%）而特异性保持（92%），从而能在更多患者中准确诊断多发性硬化症。
