Wang Yan, Piao Jianhua
Institute of Nutrition and Food Safety, Chinese Center For Disease Control and Prevention, Beijing 100050, China.
Wei Sheng Yan Jiu. 2003 Jan;32(1):84-7.
Zinc is one of essential trace elements in humans. Zinc homeostasis is mainly regulated by the changes of intestinal absorption efficiency and endogenous excretion, namely the regulation of bioavailability. Studies on zinc bioavailability play an important role on a thorough understanding of zinc metabolism and reliable assessment on population zinc status. Stable isotopes are valuable tools for research on mineral bioavailability and metabolism. Zinc stable isotopes can be used for all population as tracers with no exposure to radiation. Since 1980s' many different stable isotope methods have been applied to the zinc metabolism research. However, limitations to these approaches and methodological problems remain to be resolved. In addition, the introduction and development of new analytical instruments not only make it possible to use zinc stable isotope, also greatly diminish the difficulty and cost on it. The paper is mainly focused on the zinc bioavailability and present a review of its development history, main research methods and analytical skills.
锌是人体必需的微量元素之一。锌稳态主要通过肠道吸收效率和内源性排泄的变化来调节，即生物利用度的调节。锌生物利用度的研究对于深入理解锌代谢以及可靠评估人群锌营养状况具有重要作用。稳定同位素是研究矿物质生物利用度和代谢的重要工具。锌稳定同位素可作为示踪剂用于所有人群，且无辐射暴露风险。自20世纪80年代以来，许多不同的稳定同位素方法已应用于锌代谢研究。然而，这些方法的局限性和方法学问题仍有待解决。此外，新分析仪器的引入和发展不仅使锌稳定同位素的应用成为可能，也大大降低了其难度和成本。本文主要聚焦于锌生物利用度，并对其发展历史、主要研究方法和分析技术进行综述。
