Chung Brian, Wong Virginia, Ip Patrick
Department of Paediatrics & Adolescent Medicine, The University of Hong Kong, Pokfulam, China.
J Child Neurol. 2003 Mar;18(3):217-9. doi: 10.1177/08830738030180030201.
Our objective was to study the prevalence of neuromuscular diseases in Chinese children. A prospective study of neuromuscular diseases in Chinese children was conducted from 1985 to 2001 in Hong Kong, which is a city in southern China. The population census of June 30, 2001, was used to calculate the prevalence of neuromuscular diseases in Chinese children. Altogether, 332 children aged < 19 years at first assessment with neuromuscular diseases confirmed by using electromyography, muscle biopsy, and/or molecular genetic study were included in the study. Of these, 228 (68%) had inherited and 104 (32%) had noninherited neuromuscular diseases. Of the inherited neuromuscular diseases, the most common were the dystrophinopathies, including Duchenne muscular dystrophy (n = 66) and Becker muscular dystrophy (n = 8). Spinal muscular atrophy was the second most common (n = 61). Of the noninherited neuromuscular disorders, myasthenia gravis was the most common (n = 62, 60%). Nearly 88% of the cases of myasthenia gravis were ocular type. The prevalence rate of neuromuscular diseases in June 2001 (n = 291 surviving) is estimated to be 214 x 10(-6). The estimated prevalence rate of neuromuscular diseases in our Chinese children is 1 in 4669.
我们的目标是研究中国儿童神经肌肉疾病的患病率。1985年至2001年在中国南方城市香港对中国儿童神经肌肉疾病进行了一项前瞻性研究。以2001年6月30日的人口普查数据来计算中国儿童神经肌肉疾病的患病率。共有332名首次评估时年龄小于19岁且经肌电图、肌肉活检和/或分子遗传学研究确诊患有神经肌肉疾病的儿童纳入本研究。其中，228名（68%）患有遗传性神经肌肉疾病，104名（32%）患有非遗传性神经肌肉疾病。在遗传性神经肌肉疾病中，最常见的是肌营养不良症，包括杜氏肌营养不良症（n = 66）和贝克肌营养不良症（n = 8）。脊髓性肌萎缩症是第二常见的（n = 61）。在非遗传性神经肌肉疾病中，重症肌无力最为常见（n = 62，占60%）。近88%的重症肌无力病例为眼肌型。2001年6月神经肌肉疾病的患病率（n = 291名存活者）估计为214×10⁻⁶。我们所研究的中国儿童神经肌肉疾病的估计患病率为1/4669。
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