Heemskerk Jeroen, Kitslaar Peter
Department of Surgery, University Hospital Maastricht, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands.
World J Surg. 2003 Jun;27(6):744-7. doi: 10.1007/s00268-003-6691-7. Epub 2003 May 13.
The acute compartment syndrome is caused by bleeding or edema in a closed muscle compartment surrounded by fascia and bone. It is characterized by increased intracompartmental pressure and decreased tissue perfusion. Well-known causative incidents are acute trauma and reperfusion after treatment for acute arterial obstruction. Most commonly the lower leg is involved. Inadequate therapy of the syndrome usually leads to muscle ischemia, rhabdomyolysis, and renal insufficiency. Perioperative morbidity and mortality are high. Although compartment syndromes can be caused by various factors, up until now no comparative studies have been published on clinical outcome of compartment syndromes of different origin. In this retrospective study we analyzed 40 successive cases of fasciotomy for acute lower leg compartment syndrome to study whether different causes of the syndrome lead to different clinical outcomes. We also studied other predictive factors for clinical outcome. The causes for the compartment syndromes were trauma, vascular deobstruction, cardiac surgery, and gastrointestinal surgery in lithotomy position. Clinical outcome showed a mortality of 15% and serious overall morbidity. Multivariate analysis showed the only significant predictive determinant of outcome to be the age of the patient. Fasciotomy for acute compartment syndrome is associated with serious morbidity and mortality. No correlation between causative factors and clinical outcome could be found.
急性骨筋膜室综合征是由封闭的、被筋膜和骨骼包围的肌肉骨筋膜室内出血或水肿引起的。其特征是骨筋膜室内压力升高和组织灌注减少。常见的致病因素是急性创伤和急性动脉阻塞治疗后的再灌注。最常累及小腿。该综合征治疗不当通常会导致肌肉缺血、横纹肌溶解和肾功能不全。围手术期发病率和死亡率很高。虽然骨筋膜室综合征可由多种因素引起,但迄今为止尚未发表关于不同病因的骨筋膜室综合征临床结局的比较研究。在这项回顾性研究中,我们分析了40例连续的急性小腿骨筋膜室综合征切开减压术病例,以研究该综合征的不同病因是否导致不同的临床结局。我们还研究了其他临床结局的预测因素。骨筋膜室综合征的病因包括创伤、血管再通、心脏手术和截石位的胃肠道手术。临床结局显示死亡率为15%,总体严重发病率较高。多因素分析显示,唯一显著的结局预测因素是患者年龄。急性骨筋膜室综合征切开减压术与严重的发病率和死亡率相关。未发现致病因素与临床结局之间存在相关性。