接触砷和镉的人群的尿蛋白排泄情况。

Urinary protein excretion in humans exposed to arsenic and cadmium.

作者信息

Buchet Jean-Pierre, Heilier Jean-François, Bernard Alfred, Lison Dominique, Jin Taiyi, Wu Xunwei, Kong Qinhu, Nordberg Gunnar

机构信息

Unité de toxicologie industrielle et médecine du travail, Université Catholique de Louvain, Clos Chapelle-aux-Champs, 30.54, 1200 Brussels, Belgium.

出版信息

Int Arch Occup Environ Health. 2003 Mar;76(2):111-20. doi: 10.1007/s00420-002-0402-9. Epub 2002 Dec 10.

DOI:10.1007/s00420-002-0402-9

PMID:12733083

Abstract

OBJECTIVE

In mice, the renal toxicity of arsenic (As) and cadmium (Cd) has been shown to be exacerbated by the simultaneous administration of both elements. To verify the existence of such an interaction in humans, cohorts slightly (Belgian) and moderately (Chinese) exposed to both elements were examined.

METHODS

Biological indicators of exposure (Cd in urine and in blood; As in urine) and renal effect parameters (retinol binding protein (RBP); beta(2)-microglobulin (beta(2)M); albumin (ALB); N-acetyl-beta-glucosaminidase (NAG) in urine) were determined and their relationships studied by multiple regression analyses.

RESULTS

Changes in renal effect parameters could be ascribed to Cd body burden. RBP and beta(2)M urinary concentration were influenced by exposure to As only in Chinese women, directly and in interaction with Cd exposure.

CONCLUSION

A synergistic action of As on the tubular effects of Cd is observed in women moderately exposed to these elements and leads to RBP urinary excretion slightly above normal values.

摘要