McEwen Laura N, Farjo Rand, Foxman Betsy
University of Michigan, Ann Arbor, MI 48109, USA.
Pharmacoepidemiol Drug Saf. 2003 Apr-May;12(3):213-9. doi: 10.1002/pds.763.
Otitis media (OM) accounts for approximately 31 million physician visits annually, and is typically treated with antibiotics. Amoxicillin is the recommended first-line treatment; appropriate antibiotic use slows the development of resistance. We analyzed insurance claims from families of employees working at a single company to determine if OM treatments (1) matched published standards; and (2) varied by patient characteristics, type of physician practice or geographic location. Persons diagnosed with OM between 1996 and 1999 were matched to prescription drug claims for those who filled an antibiotic prescription within 3 days of diagnosis. Physicians prescribed amoxicillin for only 31% of acute cases and 19% of recurrent cases. For acute infections in children < or = 2 years the prescribed duration often matched the standard of 10 days, but for persons > 2 years the prescribed duration was often longer than the suggested duration of 5-7 days. For persons of all ages with recurrent infections, the prescribed duration was often shorter than suggested (10 days versus > or = 14 days). There were only modest variations by urban/rural location or provider type.
中耳炎(OM)每年约导致3100万人次看医生,通常使用抗生素进行治疗。阿莫西林是推荐的一线治疗药物;合理使用抗生素可减缓耐药性的发展。我们分析了一家公司员工家庭的保险理赔记录,以确定中耳炎的治疗情况:(1)是否符合已公布的标准;(2)是否因患者特征、医生执业类型或地理位置而有所不同。将1996年至1999年间被诊断为中耳炎的患者与在诊断后3天内开具抗生素处方者的处方药理赔记录进行匹配。医生仅为31%的急性病例和19%的复发性病例开具了阿莫西林。对于2岁及以下儿童的急性感染,规定疗程通常符合10天的标准,但对于2岁以上的患者,规定疗程往往长于建议的5至7天。对于所有年龄段复发性感染的患者,规定疗程往往短于建议疗程(10天对14天及以上)。城乡位置或医疗服务提供者类型的差异不大。