Whole-body utilization of n-3 PUFA in n-6 PUFA-deficient rats.

作者信息

Bazinet Richard P, Douglas Holly, Cunnane Stephen C

机构信息

Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario MS 3E2, Canada.

出版信息

Lipids. 2003 Feb;38(2):187-9. doi: 10.1007/s11745-003-1050-8.

We evaluated the utilization of a-linolenic acid (18:3n-3) in growing rats consuming a diet deficient in n-6 PUFA. After 90 d, whole-body 18:3n-3 accumulation was 55% lower, total n-3 PUFA accumulation was 21% lower, and 18:3n-3 disappearance was 14% higher in n-6 PUFA-deficient rats. Part of the reduction of whole-body 18:3n-3 in n-6 PUFA-deficient rats was due to the 25% increase in net conversion of 18:3n-3 to long-chain n-3 PUFA. Despite adequate 18:3n-3 intake, n-6 PUFA deficiency decreased the accumulation of 18:3n-3 and total n-3 PUFA.