Souhrada J F, Dickey D W
Respir Physiol. 1976 Feb;26(1):27-40. doi: 10.1016/0034-5687(76)90049-9.
The phenomenon of spontaneous contractions as measured in vivo and in vitro (isolated guinea pig trachea) is described. In vitro contractility is defined in terms of active tension (AT), the maximum rate of tension development (dT/dt) and time to peak tension (TTP). The length-tension relationship was established for spontaneous contractions of isolated guinea pig trachea. The effect of the temperature on spontaneous activities was also studied. An increase in temperature from 37.5 to 41.5C produced an increase in the maximum rate of tension development (dT/dt( and a decrease in the time to peak tension (TTP). A comparable decrease in temperature, from 37.5 to 33.5C produced slight but not statistically significa-nt increases in active tension, dT/dt and TTP. Frequency of the spontaneous contractions varied directly with changes in temperature. Employing a micro-strain-gauge transducer a rhytmic change of tracheal diameter has been observed in vivo in both guinea pigs and rabbits. Administration of atropine and isoproterenol in those experiments transiently abolished the appearance of these rhythmic changes of tracheal diameter.
本文描述了在体内和体外（分离的豚鼠气管）测量到的自发收缩现象。体外收缩性是根据主动张力（AT）、张力发展的最大速率（dT/dt）和达到峰值张力的时间（TTP）来定义的。建立了分离的豚鼠气管自发收缩的长度-张力关系。还研究了温度对自发活动的影响。温度从37.5℃升高到41.5℃会导致张力发展的最大速率（dT/dt）增加，达到峰值张力的时间（TTP）缩短。温度从37.5℃降至33.5℃会使主动张力、dT/dt和TTP略有增加，但无统计学意义。自发收缩的频率随温度变化而直接变化。使用微应变计传感器，在豚鼠和兔子体内均观察到气管直径的节律性变化。在这些实验中，给予阿托品和异丙肾上腺素可暂时消除气管直径这些节律性变化的出现。
