Lyszkiewicz Dorothy A, Levichek Zina, Kozer Eran, Yagev Yaron, Moretti Myla, Hard Marjie, Koren Gideon
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada.
Pediatr Nephrol. 2003 Jul;18(7):675-8. doi: 10.1007/s00467-003-1088-2. Epub 2003 May 7.
Currently, a suspension of crushed tablets of amlodidpine is widely used in children with hypertension without knowledge of its bioavailability. A comparative bioavailability study of a tablet and suspension formulation of amlodipine was completed in 20 healthy adult volunteers. Bioequivalence of the suspension was not different from the tablets. These results support the use of the suspension in children who cannot take the tablet.
目前，氨氯地平压碎片的混悬液在不明其生物利用度的情况下被广泛用于高血压儿童。一项针对氨氯地平片剂和混悬液制剂的比较生物利用度研究在20名健康成年志愿者中完成。该混悬液的生物等效性与片剂无异。这些结果支持在无法服用片剂的儿童中使用该混悬液。
