Sheraz Muhammad Ali, Ahsan Syed Furqan, Khan Marium Fatima, Ahmed Sofia, Ahmad Iqbal
Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, 51 Deh Tor, Toll Plaza, Super Highway, Gadap Road, Karachi 74600, Pakistan.
J Pharm (Cairo). 2016;2016:8961621. doi: 10.1155/2016/8961621. Epub 2016 Oct 16.
Amlodipine (AD) is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone or in combination with other drugs. AD is a photosensitive drug and requires protection from light. A number of workers have tried to formulate various conventional and nonconventional dosage forms of AD. This review highlights all the formulations that have been developed to achieve maximum stability with the desired therapeutic action for the delivery of AD such as fast dissolving tablets, floating tablets, layered tablets, single-pill combinations, capsules, oral and transdermal films, suspensions, emulsions, mucoadhesive microspheres, gels, transdermal patches, and liposomal formulations.
氨氯地平（AD）是一种钙通道阻滞剂，主要用于治疗高血压和心绞痛。然而，最新研究结果表明，其功效不仅限于治疗心血管疾病，因为它已显示出具有抗氧化活性，并在细胞凋亡中发挥重要作用。因此，它也单独或与其他药物联合用于治疗脑血管中风、神经退行性疾病、白血病、乳腺癌等。氨氯地平是一种光敏药物，需要避光保存。许多研究人员试图制备氨氯地平的各种传统和非传统剂型。这篇综述重点介绍了为实现最大稳定性以及氨氯地平所需治疗作用而开发的所有制剂，如速溶片、漂浮片、多层片、单片复方制剂、胶囊、口服和透皮膜剂、混悬剂、乳剂、粘膜粘附微球、凝胶、透皮贴剂和脂质体制剂。
