Ammann R W, Deyhle P, Sulser H
Scand J Gastroenterol. 1976;11(3):233-40.
A clinical study of a family (Sch.) with a high incidence of death from gastric cancer in the second generation is presented. Endoscopic and/or surgical evaluation of the stomach, upper small intestine, and colon in 14 mainly asymptomatic members of the third and fourth generations revealed single or multiple (solitary) papillary adenomas in the colon or jejunum in 2 members each of the two generations. In addition, single or multiple hyperplastic polyps in the stomach or colon were found in 5 members, in 4 of them in association with papillary adenomas. The findings in family Sch. are consistent with 'minor' adenomatous polyposis coli associated with gastric carcinoma. Gastric carcinoma probably represents another phenotype among the vast variety of extra-colonic and extra-alimentary neoplastic changes known to occur in association with familial polyposis coli (FPC). The relationship of hyperplastic polyps to papillary adenoma in the colon and to gastric carcinoma respectively is discussed. Finally, evidence for a genetic relationship between family Sch. and a case with probable FPC is presented.
本文介绍了一个家族（Sch.）的临床研究，该家族第二代胃癌死亡率较高。对第三代和第四代的14名主要无症状成员的胃、上小肠和结肠进行内镜和/或手术评估，发现两代中各有2名成员在结肠或空肠中有单个或多个（孤立性）乳头状腺瘤。此外，在5名成员中发现胃或结肠中有单个或多个增生性息肉，其中4名与乳头状腺瘤相关。Sch.家族的这些发现与与胃癌相关的“轻度”腺瘤性结肠息肉病一致。胃癌可能是已知与家族性结肠息肉病（FPC）相关的各种结肠外和消化道外肿瘤性变化中的另一种表型。分别讨论了增生性息肉与结肠乳头状腺瘤以及与胃癌的关系。最后，给出了Sch.家族与一例可能患有FPC的病例之间存在遗传关系的证据。
