Bosma Hans, van Boxtel Martin P J, Ponds Rudolf W H M, Houx Peter J, Burdorf Alex, Jolles Jelle
Maastricht Brain and Behavior Institute, Maastricht University, Department of Psychiatry and Neuropsychology, PO Box 616, 6200 MD Maastricht, The Netherlands.
Exp Aging Res. 2003 Jan-Mar;29(1):33-45. doi: 10.1080/03610730303710.
Little is known about whether persons with mentally demanding jobs are protected against cognitive impairment and whether this association is independent of intellectual abilities and other confounders. Longitudinal data from the Maastricht Aging Study (MAAS) were used to examine this association. After the 1993-1995 baseline examination, there was a first 3-year follow-up examination (1996-1998) among 630 men and women, aged 50 to 80, who exhibited no cognitive impairment at baseline. Persons with mentally demanding jobs had lower risks of developing cognitive impairment during follow-up (36 cases), compared with persons without such jobs (odds ratio = 0.79; 95% confidence interval: 0.65-0.96). About 1.5% of the persons with high mental work demands developed impairment compared to 4% of the persons with few work demands. The protective effect was independent of intellectual abilities and other confounders. Our findings provide evidence that continued and potentially modifiable mental stimulation during adult life may protect men and women against cognitive impairment.
对于从事脑力要求高的工作的人是否能预防认知障碍，以及这种关联是否独立于智力能力和其他混杂因素，我们知之甚少。马斯特里赫特衰老研究（MAAS）的纵向数据被用于检验这种关联。在1993 - 1995年的基线检查之后，对630名年龄在50至80岁、基线时无认知障碍的男性和女性进行了首次为期3年的随访检查（1996 - 1998年）。与没有此类工作的人相比，从事脑力要求高的工作的人在随访期间发生认知障碍的风险较低（36例）（优势比 = 0.79；95%置信区间：0.65 - 0.96）。从事高脑力工作要求的人中约1.5%出现了认知障碍，而工作要求低的人中这一比例为4%。这种保护作用独立于智力能力和其他混杂因素。我们的研究结果提供了证据，表明成年期持续的、可能可改变的脑力刺激可能保护男性和女性免受认知障碍。
