印度人群中HLA - B12与多发性硬化症的关联。

Association of HLA-B12 with multiple sclerosis in India.

作者信息

Wadia N H, Trikannad V S, Krishnaswamy P R

机构信息

Laboratory of Immunology in the Dept. of Pathology, Jaslok Hospital and Research Centre, Bombay, India.

出版信息

Tissue Antigens. 1980 Jan;15(1):90-3. doi: 10.1111/j.1399-0039.1980.tb00891.x.

DOI:10.1111/j.1399-0039.1980.tb00891.x

PMID:12735339

Abstract

In Indian patients with Multiple Sclerosis it was observed, upon testing for serum determinable histocompatibility antigens, that HLA-B12 antigen was present in excess (77.7%), in comparison with normal controls (13.8%). In fact, in the sub-group of 'clinically definite' patients, the B12 antigen excess was remarkable (84%). These preliminary findings seem to point to a different immunogenetic profile of Indian MS patients in comparison with Western and Japanese series. Relevant published information relating to the HLA-B12 alleles in disease processes is discussed in order to provide a basis for further work.

摘要

在对印度多发性硬化症患者进行血清可测定组织相容性抗原检测时发现，与正常对照组（13.8%）相比，HLA - B12抗原存在过量情况（77.7%）。事实上，在“临床确诊”患者亚组中，B12抗原过量情况显著（84%）。这些初步研究结果似乎表明，与西方和日本的病例系列相比，印度多发性硬化症患者具有不同的免疫遗传特征。文中讨论了已发表的与疾病过程中HLA - B12等位基因相关的信息，以便为进一步研究提供基础。