印度人中多发性硬化症的人类白细胞抗原
HLA antigens in multiple sclerosis amongst Indians.
作者信息
Wadia N H, Trikannad V S, Krishnaswamy P R
出版信息
J Neurol Neurosurg Psychiatry. 1981 Sep;44(9):849-51. doi: 10.1136/jnnp.44.9.849.
The infrequency of multiple sclerosis in India may have genetic implications. We found (a) the HLA-A3 and HLA-B7 haplotypes amongst Indians to be lower than those reported in Caucasians, (b) no excess of HLA-A3 and HLA-B7 amongst our 27 multiple sclerosis patients compared to 330 controls; instead it was the reverse, (c) HLA-B12 as high as 74% in the "clinically definite" cases, against only 9% in controls, (d) a significant relative risk of MS amongst Indians with HLA-B12 haplotype. Attention is drawn to th higher incidence of MS amongst the small Parsee community and the high association of HLA-B12 in these patients.
多发性硬化症在印度发病率较低，这可能具有遗传学意义。我们发现：（a）印度人中HLA - A3和HLA - B7单倍型低于高加索人所报告的水平；（b）在我们的27例多发性硬化症患者中，与330名对照相比，HLA - A3和HLA - B7并无过量；相反，情况正好相反；（c）在“临床确诊”病例中，HLA - B12高达74%，而对照组中仅为9%；（d）携带HLA - B12单倍型的印度人患多发性硬化症的相对风险显著。值得注意的是，在人数较少的帕西人群体中多发性硬化症发病率较高，且这些患者中HLA - B12的关联性也很高。
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