Fehr K A, Kalant H, LeBlanc A E
Science. 1976 Jun 18;192(4245):1249-51. doi: 10.1126/science.1273591.
Acute oral administration of cannabis extract to rats (tetrahydrocannabinol dose, 10 milligrams per kilogram) impaired maze learning. The impairment was more marked after ten daily doses of the same size. After 1, 2, or 3 months' pretreatment with the same daily dose, followed by a 25-day drug-free period, no residual learning impairment was found. However, 6 months of daily administration of cannabis (tetrahydrocannabinol, 20 milligrams per kilogram) or alcohol (6 grams per kilogram) produced significant residual impairment of learning of maze and motor coordination tasks, 2 months or more after the last drug administration.
给大鼠急性口服大麻提取物（四氢大麻酚剂量为每千克10毫克）会损害迷宫学习能力。在连续十天给予相同剂量后，这种损害更为明显。在以相同日剂量进行1、2或3个月的预处理，随后有25天的无药期后，未发现残留的学习障碍。然而，连续6个月每日给予大麻（四氢大麻酚，每千克20毫克）或酒精（每千克6克），在最后一次给药后2个月或更长时间，会对迷宫学习和运动协调任务产生显著的残留损害。
