Miller S S, Wolf A M, Arnaud C D
Science. 1976 Jun 25;192(4246):1340-3. doi: 10.1126/science.1273593.
Hormones and purine nucleosides and nucleotides induced cultured bone cells to transform transiently from a spherical to a stellate shape. Cytochalasin B also induced the transformation. The change was blocked by colchicine and vinblastine, but not by lumicolchicine or cycloheximide. This morphologic transformation may provide a dynamic model of hormone action and bone cell modulation in vitro.