Hollenberg N K, Mangel R, Fung H Y
Semin Nucl Med. 1976 Apr;6(2):193-216. doi: 10.1016/s0001-2998(76)80004-9.
Radioxenon has achieved wide use for assessing tissue perfusion. Here we review its application to the kidney for assessing mean blood flow and intrarenal perfusion rates. Correlation with alternative methods in animals suggests that the initial disappearance slope provides an adequate measure of mean renal blood flow despite the theoretical limitations of this approach. The stochastic method and compartmental analysis can also provide an acceptable measure fo mean renal blood flow, but only after the slowest flow components have been removed. Compartmental analysis does, however, provide an index of cortical perfusion not available from other methods. The evidence that the rapid component of xenon washout provides an index of cortical perfusion in man is reviewed, along with insights gained from the application of this approach to human disease.
放射性氙已广泛用于评估组织灌注。在此，我们综述其在肾脏评估平均血流和肾内灌注率方面的应用。与动物实验中其他方法的相关性表明，尽管该方法存在理论局限性，但初始消失斜率仍可充分衡量平均肾血流。随机方法和房室分析也能提供可接受的平均肾血流测量值，但前提是去除最慢的血流成分。然而，房室分析确实能提供其他方法无法获得的皮质灌注指标。本文综述了氙洗脱快速成分可作为人类皮质灌注指标的证据，以及将该方法应用于人类疾病所获得的见解。
