Shanser J D, Korobkin M, Seidlitz L, Carlson E L, Shames D M
Invest Radiol. 1975 Nov-Dec;10(6):569-82. doi: 10.1097/00004424-197511000-00005.
The role of decreased renal artery perfusion pressure in redistribution of renal cortical blood flow during acute hemorrhagic hypotension is unclear. Renal artery hypotension was produced in intact dogs by an intra-aortic balloon catheter placed cephalad to the origins of the renal arteries. Renal cortical perfusion was assessed using selective renal magnification arteriography, isotopically labeled microspheres, and xenon-133 washout. After 60 minutes of decreased renal artery perfusion pressure (40 to 50 mm Hg), no changes were noted in renal cortical perfusion arteriographically. Microsphaere distribution to each cortical zone was unchanged, despite a marked decrease in total renal blood flow and in flow to each zone. 133Xe washout curves permitted two interpretations: Either redistribution of blood flow away from the cortex occurred, or parallel decrease in flow to each zone occurred without redistribution. Results indicate decreased renal artery perfusion pressure does not cause redistribution of renal cortical blood flow in our model.
肾动脉灌注压降低在急性出血性低血压期间肾皮质血流重新分布中的作用尚不清楚。通过将主动脉内球囊导管置于肾动脉起始部上方，在完整的犬体内造成肾动脉低血压。使用选择性肾放大动脉造影、同位素标记微球和氙 - 133洗脱来评估肾皮质灌注。在肾动脉灌注压降低（40至50毫米汞柱）60分钟后，动脉造影显示肾皮质灌注无变化。尽管肾总血流量及每个皮质区的血流量显著减少，但微球在每个皮质区的分布未改变。氙 - 133洗脱曲线有两种解释：要么发生了血流从皮质的重新分布，要么每个区域的血流平行减少而无重新分布。结果表明，在我们的模型中，肾动脉灌注压降低不会导致肾皮质血流的重新分布。
