Horimoto Yoshihiko, Matsumoto Mitsuhiro, Akatsu Hiroyasu, Ikari Hiroyuki, Kojima Kiyohide, Yamamoto Takayuki, Otsuka Yasushi, Ojika Kosei, Ueda Ryuzo, Kosaka Kenji
Choju Medical Institute, Fukushimura Hospital, Noyori, Toyohashi, Aichi 441-8124, Japan.
J Neurol. 2003 May;250(5):530-3. doi: 10.1007/s00415-003-1029-9.
Twenty-nine cases of both clinically and neuropathologically diagnosed dementia with Lewy bodies (DLB) were retrospectively examined for autonomic symptoms. Twenty-eight cases showed some kind of autonomic dysfunction. Urinary incontinence (97 %) and constipation (83 %) were the two most common. Although urinary retention and episodic hypotension causing syncopal attacks were less common, the frequency was still high (28 % each). There were 18 cases (62 %) with severe autonomic failure. These 28 cases showed similar tendencies, with no significant differences between the subtypes of DLB (brainstem, limbic, and neocortical types or common and pure forms). We found that DLB of all pathological subtypes exhibits some kind and level of autonomic symptoms.
对29例临床和神经病理学诊断为路易体痴呆（DLB）的患者进行回顾性自主神经症状检查。28例患者出现某种自主神经功能障碍。尿失禁（97%）和便秘（83%）是最常见的两种症状。虽然尿潴留和导致晕厥发作的发作性低血压较少见，但发生率仍然较高（均为28%）。有18例（62%）出现严重自主神经功能衰竭。这28例患者表现出相似的趋势，DLB各亚型（脑干型、边缘型和新皮质型或常见型和纯合型）之间无显著差异。我们发现，所有病理亚型的DLB均表现出某种类型和程度的自主神经症状。
