Lee Chuo-Yu, Cheng Shih-Jung, Lin Hui-Chi, Liao Yu-Lu, Chen Pei-Hao
Department of Neurology, Mackay Memorial Hospital, Taipei, Taiwan.
Graduate Institute of Chemistry, Tamkang University, New Taipei City, Taiwan.
Behav Neurol. 2018 Jul 5;2018:8320901. doi: 10.1155/2018/8320901. eCollection 2018.
Dementia with Lewy bodies (DLB) is a complex, multisymptom disorder. When making decisions regarding the treatment of DLB, the patient's quality of life (QoL) should always be the main consideration. To our knowledge, this is the first review article focusing on the QoL in DLB patients. We searched the PubMed database using the keywords "quality of life" and "dementia with Lewy bodies." Previously, no specific instrument had been developed for assessing the QoL in DLB patients. Patients with DLB have a decreased QoL compared to patients with Alzheimer's disease, which is reportedly caused by several factors including level of independence in instrumental activities of daily living, whether the patient is living with the caregiver, apathy, delusion, and dysautonomia. The direct effect of visual hallucination, sleep, and movement disorders on the QoL in DLB patients has not been previously studied. The role of cognitive function on the QoL is still controversial. In a randomized controlled study, memantine may improve the QoL in PDD or DLB patients. We concluded that it is important to develop a specific instrument to assess the QoL in DLB patients. Furthermore, there is an urgent need for large clinical trials to identify factors associated with the QoL and how they can be managed.
路易体痴呆（DLB）是一种复杂的多症状疾病。在做出关于DLB治疗的决策时，患者的生活质量（QoL）应始终是主要考虑因素。据我们所知，这是第一篇关注DLB患者生活质量的综述文章。我们使用关键词“生活质量”和“路易体痴呆”在PubMed数据库中进行了搜索。此前，尚未开发出用于评估DLB患者生活质量的特定工具。与阿尔茨海默病患者相比，DLB患者的生活质量有所下降，据报道这是由多种因素导致的，包括日常生活工具性活动的独立程度、患者是否与照顾者同住、冷漠、妄想和自主神经功能障碍。此前尚未研究视幻觉、睡眠和运动障碍对DLB患者生活质量的直接影响。认知功能对生活质量的作用仍存在争议。在一项随机对照研究中，美金刚可能会改善帕金森病痴呆（PDD）或DLB患者的生活质量。我们得出结论，开发一种评估DLB患者生活质量的特定工具很重要。此外，迫切需要进行大型临床试验，以确定与生活质量相关的因素以及如何对其进行管理。
