诱导型一氧化氮合酶基因（NOS2A）与多发性硬化症无关联。
No association of inducible nitric oxide synthase gene ( NOS2A) to multiple sclerosis.
作者信息
Blanco Yolanda, Yagüe Jordi, Graus Francesc, Saiz Albert
机构信息
Servei de Neurologia, Hospital Clínic, Villarroel 170, Barcelona 08036, Spain.
出版信息
J Neurol. 2003 May;250(5):598-600. doi: 10.1007/s00415-003-1047-7.
Nitric oxide (NO) is a nonspecific inflammatory mediator that has been involved in the pathogenesis of multiple sclerosis (MS). The influence of the promoter polymorphism of inducible NO synthase gene ( NOS2A) on susceptibility and outcome was studied in 140 MS Spanish patients and 147 healthy controls matched for sex, age, and ethnicity. No association was found between MS susceptibility, course or outcome of the disease, and NOS2A polymorphisms.
一氧化氮（NO）是一种非特异性炎症介质，它参与了多发性硬化症（MS）的发病机制。本研究在140例西班牙MS患者和147例年龄、性别及种族相匹配的健康对照者中，研究了诱导型一氧化氮合酶基因（NOS2A）启动子多态性对易感性及疾病转归的影响。未发现MS易感性、病程或疾病转归与NOS2A多态性之间存在关联。
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