Bernasconi E
Infectious Disease Unit, Department of Medicine, Regional Hospital, Lugano, Switzerland.
AIDS Read. 1999 Jul;9(4):254-6, 259-60, 266-9.
Fat redistribution (lipodystrophy) and metabolic anomalies are reported increasingly in HIV-infected patients being treated with protease inhibitors. The incidence of these side effects ranges from 5% to 75% in such patients, who often complain of spontaneous fat wasting in the face, arms, or legs, with or without central obesity. Hyperlipidemia and insulin resistance are almost always associated with lipodystrophy. We review the metabolic complications of antiretroviral therapies and discuss possible therapeutic interventions.
据报道，接受蛋白酶抑制剂治疗的HIV感染患者中，脂肪重新分布（脂肪营养不良）和代谢异常的情况越来越多。这些副作用在这类患者中的发生率为5%至75%，他们常常抱怨面部、手臂或腿部出现自发性脂肪消耗，伴有或不伴有中心性肥胖。高脂血症和胰岛素抵抗几乎总是与脂肪营养不良相关。我们回顾了抗逆转录病毒疗法的代谢并发症，并讨论了可能的治疗干预措施。
