Farinha Ascensão, Toscano Cristina, Campos Rodrigo, Bica António, Hadgraft Jonathan
Laboratório de Estudos Farmacêuticas, Lisboa, Portugal.
Drug Dev Ind Pharm. 2003 Apr;29(4):489-94. doi: 10.1081/ddc-120018383.
The release of naproxen through synthetic membranes, mounted in modified Franz-type diffusion cells, was evaluated, either from saturated solutions or from commercially available topical formulations containing 10% naproxen. The results obtained showed that the porous type synthetic membranes chosen (cellulose acetate and polyethersulphone) can be used for assessing product performance in quality control procedures. The formulations interacted with the solid membranes (silicone and EVA) to change their diffusional characteristics. However, transfer in the membrane, and not the formulation was rate controlling. These membranes could not therefore be used in assessing product release performance for quality control.
通过安装在改良型Franz扩散池中的合成膜来评估萘普生从饱和溶液或含10%萘普生的市售局部用制剂中的释放情况。所得结果表明，所选用的多孔型合成膜（醋酸纤维素和聚醚砜）可用于质量控制程序中评估产品性能。制剂与固体膜（硅酮和乙烯-醋酸乙烯共聚物）相互作用，改变了它们的扩散特性。然而，膜内的转运而非制剂是速率控制因素。因此，这些膜不能用于评估产品释放性能以进行质量控制。
