Rao I Nageshwar, Prabhakaran E N, Das Saibal Kumar, Iqbal Javed
Dr. Reddy's Research Foundation, Bollaram Road, Miyapur, Hyderabad 500 050, India.
J Org Chem. 2003 May 16;68(10):4079-82. doi: 10.1021/jo020559c.
An efficient improved procedure for the synthesis of beta-acetamido carbonyl compounds is developed by a cobalt(II) chloride-catalyzed three-component coupling protocol. The procedure is also amenable to the synthesis of gamma-lactams by a three-component coupling reaction with use of 2-carbomethoxybenzaldehyde. The beta-acetamido carbonyl compounds derived from 2-carbomethoxybenzaldehyde are useful intermediates as they can be transformed to the corresponding gamma-lactams on treatment with base.
通过氯化钴（II）催化的三组分偶联方案，开发了一种高效改进的合成β-乙酰氨基羰基化合物的方法。该方法也适用于通过使用2-甲氧羰基苯甲醛的三组分偶联反应合成γ-内酰胺。由2-甲氧羰基苯甲醛衍生的β-乙酰氨基羰基化合物是有用的中间体，因为它们在用碱处理时可以转化为相应的γ-内酰胺。
