Stremple J E, Thomas H, Sakach V, Trelka D
Surgery. 1976 Jul;80(1):4-13.
Awake pigs were rapidly bled 40% of total blood volume to induce hemorrhagic shock. Immediately after the induction of shock, all pigs received a single intravenous injection of radioactive-labeled glucose-U-14C. Simultaneously with glucose-U-14C injection, ten pigs received single central intravenous injections of unlabeled 50% glucose, four pigs received equiosmolar 25% mannitol, six did not receive either 50% glucose or mannitol, and two received 50% glucose plus insulin. Mean arterial pressure with 50% glucose was 89.9 mm. Hg at 15 minutes of shock and significantly higher than without 50% glucose, 48.3 mm. Hg or after mannitol, 46.7 mm. Hg (P = 0.05). Mean cardiac output at 10 minutes of shock with 50% glucose was 2.24 L. per minute and significantly higher than with mannitol, 1.34 L. per minute, or without 50% glucose, 0.94 L. per minute (P = 0.05.). Evidence for increased anaerobic myocardial utilization of the administered unlabeled 50% glucose was shown by a 12% greater production of unlabeled lactate in the venous coronary sinus blood from unlabeled 50% glucose in contrast to those not given 50% glucose at 10 minutes after shock (P = 0.05). Also, 50% glucose significantly increased mean arterial pressure, cardiac output, and survival over both control groups.
将清醒的猪快速放血至总血容量的40%以诱导失血性休克。休克诱导后立即给所有猪单次静脉注射放射性标记的葡萄糖-U-14C。在注射葡萄糖-U-14C的同时，10头猪单次经中心静脉注射未标记的50%葡萄糖，4头猪接受等渗的25%甘露醇，6头猪既未接受50%葡萄糖也未接受甘露醇，2头猪接受50%葡萄糖加胰岛素。注射50%葡萄糖的猪在休克15分钟时平均动脉压为89.9毫米汞柱，显著高于未注射50%葡萄糖的猪（48.3毫米汞柱）或注射甘露醇的猪（46.7毫米汞柱）（P = 0.05）。注射50%葡萄糖的猪在休克10分钟时的心输出量为每分钟2.24升，显著高于注射甘露醇的猪（每分钟1.34升）或未注射50%葡萄糖的猪（每分钟0.94升）（P = 0.05）。与休克10分钟时未注射50%葡萄糖的猪相比，注射未标记的50%葡萄糖的猪的冠状静脉窦血中未标记乳酸的生成量增加了12%，这表明给予的未标记50%葡萄糖的无氧心肌利用率增加（P = 0.05）。此外，50%葡萄糖显著提高了平均动脉压、心输出量，并使生存率高于两个对照组。
