肽聚糖可诱导人中性粒细胞表面的激活标记物CD66b发生动员，但对嗜酸性粒细胞无此作用。
Peptidoglycan induces mobilization of the surface marker for activation marker CD66b in human neutrophils but not in eosinophils.
作者信息
Mattsson Eva, Persson Terese, Andersson Pia, Rollof Jan, Egesten Arne
机构信息
Department of Infectious Diseases, University Hospital, Lund University, Lund, Sweden.
出版信息
Clin Diagn Lab Immunol. 2003 May;10(3):485-8. doi: 10.1128/cdli.10.3.485-488.2003.
Abstract
Peptidoglycan from Staphylococcus aureus mobilized CD66b in human neutrophils but did not upregulate surface activation markers in eosinophils. In addition, Toll-like receptor 2, implicated in the recognition of peptidoglycan, was detected on the surface of resting neutrophils but not on eosinophils. These findings suggest roles for neutrophils but not eosinophils in innate recognition of peptidoglycan.
摘要
金黄色葡萄球菌的肽聚糖可调动人类嗜中性粒细胞中的CD66b，但不会上调嗜酸性粒细胞表面的激活标志物。此外，参与肽聚糖识别的Toll样受体2在静息嗜中性粒细胞表面可检测到，但在嗜酸性粒细胞表面未检测到。这些发现表明嗜中性粒细胞而非嗜酸性粒细胞在肽聚糖的天然识别中发挥作用。
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2
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3
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