视网膜-膝状体特异性的眼间分离独立于正常神经元活动。
Eye-specific retinogeniculate segregation independent of normal neuronal activity.
作者信息
Huberman Andrew D, Wang Guo-Yong, Liets Lauren C, Collins Odell A, Chapman Barbara, Chalupa Leo M
机构信息
Center for Neuroscience, School of Medicine, University of California, Davis, CA 95616, USA.
出版信息
Science. 2003 May 9;300(5621):994-8. doi: 10.1126/science.1080694.
Abstract
The segregation of initially intermingled left and right eye inputs to the dorsal lateral geniculate nucleus (DLGN) during development is thought to be in response to precise spatial and temporal patterns of spontaneous ganglion cell activity. To test this hypothesis, we disrupted the correlated activity of neighboring ganglion cells in the developing ferret retina through immunotoxin depletion of starburst amacrine cells. Despite the absence of this type of correlated activity, left and right eye inputs segregated normally in the DLGN. By contrast, when all spontaneous activity was blocked, the projections from the two eyes remained intermingled. Thus, certain features of normal neural activity patterns are not required for the formation of eye-specific projections to the DLGN.
摘要
在发育过程中，最初混合的左眼和右眼输入到背外侧膝状核（DLGN）的分离被认为是对自发神经节细胞活动的精确空间和时间模式的反应。为了验证这一假设，我们通过免疫毒素耗尽星爆无长突细胞来破坏发育中的雪貂视网膜中相邻神经节细胞的相关活动。尽管缺乏这种类型的相关活动，但左眼和右眼输入在DLGN中仍正常分离。相比之下，当所有自发活动被阻断时，来自两只眼睛的投射仍保持混合。因此，形成到DLGN的眼特异性投射不需要正常神经活动模式的某些特征。
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