伊曲康唑和特比萘芬对利什曼原虫前鞭毛体的作用。
Effect of itraconazole and terbinafine on Leishmania promastigotes.
作者信息
Zakai Haytham A, Zimmo Sameer Kh, Fouad Mahmoud A H
机构信息
Medical Technology Program, Faculty of Medicine and Allied Sciences, King Abdulaziz University, P.O. Box 80205, Jeddah 21589, Saudi Arabia.
出版信息
J Egypt Soc Parasitol. 2003 Apr;33(1):97-107.
The antiproliferative effect induced in vitro by two antifungal compounds, the azole itraconazole and the allylamine terbinafine on Leishmania major, L. donovani and L. mexicana promastigotes are reported. Treatment of promastigotes cultures with itraconazole or with terbinafine induced growth arrest with L. major but neither with L. donovani nor with L. mexicana. Concentrations of 0.75 microl/l or more of itraconazole induced cell lysis after 72 hours with L. major. However, even relatively large concentrations of terbinafine (2.0 microl/l) did not induce cell lysis. For L. major, the IC 50 for itraconazole and terbinafine were 0.31 microl/l and 3.3 microl/l respectively.
据报道，两种抗真菌化合物（唑类的伊曲康唑和烯丙胺类的特比萘芬）在体外对硕大利什曼原虫、杜氏利什曼原虫和墨西哥利什曼原虫前鞭毛体具有抗增殖作用。用伊曲康唑或特比萘芬处理前鞭毛体培养物，可使硕大利什曼原虫生长停滞，但对杜氏利什曼原虫和墨西哥利什曼原虫均无此作用。72小时后，浓度为0.75微升/升或更高的伊曲康唑可导致硕大利什曼原虫细胞裂解。然而，即使是相对高浓度的特比萘芬（2.0微升/升）也不会诱导细胞裂解。对于硕大利什曼原虫，伊曲康唑和特比萘芬的半数抑制浓度（IC50）分别为0.31微升/升和3.3微升/升。
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