Strakowski Stephen M, Del Bello Melissa P, Adler Caleb M, Keck Paul E
Department of Psychiatry, University of Cincinnati College of Medicine, PO Box 670559, Cincinnati, OH 45267-0559, USA.
Expert Opin Pharmacother. 2003 May;4(5):751-60. doi: 10.1517/14656566.4.5.751.
Atypical antipsychotic medications are widely used for the treatment of bipolar disorder. Most empirical support suggests that these medications are efficacious in the treatment of acute mania, but there is considerably less support for the utility of these drugs in other phases of bipolar disorder. However, it is likely that several of these drugs will demonstrate efficacy in relapse prevention, and perhaps antidepressant efficacy in bipolar disorder as more studies are conducted. Atypical antipsychotics offer different side effect profiles than older antipsychotics, which may be of benefit for some patients. Consequently, atypical antipsychotics provide an important treatment option for bipolar patients.
非典型抗精神病药物被广泛用于治疗双相情感障碍。大多数实证支持表明，这些药物在治疗急性躁狂发作方面是有效的，但对于这些药物在双相情感障碍其他阶段的效用，支持的证据要少得多。然而，随着更多研究的开展，这些药物中的几种可能会在预防复发方面显示出疗效，甚至在双相情感障碍中可能具有抗抑郁疗效。非典型抗精神病药物与 older antipsychotics相比，副作用有所不同，这可能对某些患者有益。因此，非典型抗精神病药物为双相情感障碍患者提供了一种重要的治疗选择。 （注：原文中“older antipsychotics”未准确翻译，可能是表述有误，推测原文想表达的是“传统抗精神病药物”之类的意思）
