Malinow Roberto
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):707-14. doi: 10.1098/rstb.2002.1233.
Activity-dependent changes in synaptic function are believed to underlie the formation of memories. A prominent example is long-term potentiation (LTP), whose mechanisms have been the subject of considerable scrutiny over the past few decades. I review studies from our laboratory that support a critical role for AMPA receptor trafficking in LTP and experience-dependent plasticity.
突触功能的活动依赖性变化被认为是记忆形成的基础。一个突出的例子是长时程增强(LTP),在过去几十年里,其机制一直是大量研究的主题。我回顾了我们实验室的研究,这些研究支持AMPA受体转运在LTP和经验依赖性可塑性中起关键作用。