Cattley Russell C
Amgen Inc., Thousand Oaks, California 91320, USA.
Microsc Res Tech. 2003 Jun 1;61(2):179-84. doi: 10.1002/jemt.10327.
Peroxisome proliferators cause increases in liver mass in rodents, linked to changes in cell proliferation and cell death of hepatocytes. These effects are reversible upon cessation of treatment. The underlying mechanism of the response in rodent liver is complex, but clearly dependent on activation of the nuclear receptor PPARalpha. Other signaling pathways have been implicated in this response, but evidence is mixed. Differing sensitivity among various species to effects of peroxisome proliferators has been associated with differences in PPARalpha expression and function. Changes in cell proliferation and cell death in neoplastic hepatocytes also have been found in liver tumors caused by long-term treatment with peroxisome proliferators.
过氧化物酶体增殖剂会导致啮齿动物肝脏质量增加，这与肝细胞的细胞增殖和细胞死亡变化有关。停止治疗后，这些影响是可逆的。啮齿动物肝脏中这种反应的潜在机制很复杂，但显然依赖于核受体PPARα的激活。其他信号通路也与这种反应有关，但证据不一。不同物种对过氧化物酶体增殖剂作用的敏感性差异与PPARα表达和功能的差异有关。长期用过氧化物酶体增殖剂治疗引起的肝肿瘤中也发现了肿瘤性肝细胞的细胞增殖和细胞死亡变化。
