艾氏腹水癌细胞对琥珀酸盐的转运与氧化作用
The transport and oxidation of succinate by Ehrlich ascites-tumour cells.
作者信息
Spencer T L
出版信息
Biochem J. 1976 Oct 15;160(1):121-3. doi: 10.1042/bj1600121.
Abstract
The transport and oxidation of succinate by functionally intact Ehrlich ascites-tumour cells was investigated. On the basis of pH dependence and inhibitor sensitivity it was concluded that succinate may be transported across the cell membrane by the organic anion carrier system. Thus the ability of isolated Ehrlich cells to oxidize succinate is real, and is not necessarily a result of damage to cell integrity.
摘要
研究了功能完整的艾氏腹水癌细胞对琥珀酸的转运和氧化。基于pH依赖性和抑制剂敏感性，得出结论：琥珀酸可能通过有机阴离子载体系统跨细胞膜转运。因此，分离的艾氏细胞氧化琥珀酸的能力是真实的，不一定是细胞完整性受损的结果。
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