苯氟隆及其两种代谢产物对P388小鼠白血病细胞和艾氏腹水癌细胞呼吸过程的影响。
Effects of benfluron and its two metabolites on respiratory processes in P388 murine leukemia and Ehrlich ascites cells.
作者信息
Miko M, Krepelka J, Melka M
机构信息
Department of Microbiology, Biochemistry and Biology, Slovak Technical University, Bratislava.
出版信息
Biochem Pharmacol. 1991 Dec 11;42 Suppl:S214-6. doi: 10.1016/0006-2952(91)90413-y.
This paper presents data on the effects of benfluron and its two metabolites DBF and NOBF on both endogenous and exogenous, respiration in the presence of succinate as substrate, of both P388 murine leukemia and Ehrlich ascites carcinoma cells. The most efficient inhibitors of endogenous and exogenous respiration were benfluron and DBF. NOBF did not interfere with respiratory processes in Ehrlich cells, even at quite high concentration. BF and DBF exert an almost identical inhibitory effect on exogenous respiration, the least effective being NOBF (Ehrlich cells). The decrease in the respiratory rates in cancer cells might be due to the effects of benfluron and its metabolites on the cell membrane. P388 murine leukemia cells are less "sensitive" than Ehrlich ascites cells.
本文介绍了苯氟隆及其两种代谢物DBF和NOBF对P388小鼠白血病细胞和艾氏腹水癌细胞内源性和外源性呼吸作用的影响数据，呼吸作用以琥珀酸盐作为底物。内源性和外源性呼吸作用最有效的抑制剂是苯氟隆和DBF。即使在相当高的浓度下，NOBF也不会干扰艾氏细胞中的呼吸过程。BF和DBF对外源性呼吸作用具有几乎相同的抑制作用，而NOBF（对艾氏细胞）的抑制作用最小。癌细胞呼吸速率的降低可能是由于苯氟隆及其代谢物对细胞膜的作用。P388小鼠白血病细胞比艾氏腹水细胞“敏感性”更低。
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