水溶液中丁基苯与2-羟丙基-β-环糊精的络合作用

Complexation of butylbenzenes with 2-hydroxypropyl-cyclodextrins in aqueous solution.

作者信息

Saito Yoshihiro, Hashizaki Kaname, Taguchi Hiroyuki, Ogawa Naotake

机构信息

College of Pharmacy, Nihon University, Chiba, Japan.

出版信息

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2003 May;38(5):771-7. doi: 10.1081/ese-120018590.

DOI:10.1081/ese-120018590

PMID:12744431

Abstract

The stability constants for the inclusion of butylbenzenes (BBs) with 2-hydroxypropyl-cyclodextrins (2HP-CDs) in aqueous solution have been determined using the static head-space method. The 1:1 stability constants were obtained by this method. For the complexation of BBs by 2HP-alpha-CD, the order of stability constants was n-BB > isoBB > tert-BB. In contrast, the order for complexation of BBs by 2HP-beta-CD was the opposite: tert-BB > isoBB > n-BB. The order of the stability constants by 2HP-gamma-CD was similar to that of 2HP-beta-CD, but the values of the stability constants were not significantly different in the BB types. In addition, the binding effects are discussed in relation to the different alkyl groups of BBs.

摘要

采用静态顶空法测定了水溶液中丁基苯（BBs）与2-羟丙基环糊精（2HP-CDs）包合的稳定常数。通过该方法获得了1:1的稳定常数。对于2HP-α-CD与BBs的络合，稳定常数的顺序为正丁基苯＞异丁基苯＞叔丁基苯。相反，2HP-β-CD与BBs络合的顺序则相反：叔丁基苯＞异丁基苯＞正丁基苯。2HP-γ-CD的稳定常数顺序与2HP-β-CD相似，但在不同类型的BBs中，稳定常数的值没有显著差异。此外，还讨论了与BBs不同烷基相关的结合效应。