Callicott Joseph H
Unit on Functional MRI Clinical Brain Disorders, Branch NIMH/NIH, Building 10, Room 4D-20, MSC 1389, Bethesda, MD 20892-1389, USA.
Curr Opin Neurobiol. 2003 Apr;13(2):256-60. doi: 10.1016/s0959-4388(03)00041-2.
Functional magnetic resonance imaging is a surprisingly versatile tool in the quest for disentangling the complexities of mental illnesses such as schizophrenia. Yet, the identification of pathognomonic physiological features of the illness or even a consensus regarding the interpretation of reported findings remain unfulfilled goals, in spite of the increasing sophistication of this technology. Nonetheless, by providing quantification of brain function during various cognitive challenges, functional MRI has been used to leap ahead of these quandaries to identify relationships between genetic variation and brain function. By examining recent findings and efforts to link these findings to genes, this article will review these exciting developments in schizophrenia research.
在探索诸如精神分裂症等精神疾病的复杂性时，功能磁共振成像（Functional magnetic resonance imaging）是一种出奇通用的工具。然而，尽管这项技术日益成熟，但识别该疾病的特征性生理特征，甚至就所报告研究结果的解释达成共识，仍是尚未实现的目标。尽管如此，通过在各种认知挑战期间对脑功能进行量化，功能磁共振成像已被用于跨越这些困境，以识别基因变异与脑功能之间的关系。通过审视近期的研究发现以及将这些发现与基因联系起来的努力，本文将回顾精神分裂症研究中的这些令人振奋的进展。
