Benum P, Lyng S, Bo O, Rafn I, Haffner J F
Acta Orthop Scand. 1976 Apr;47(2):158-66. doi: 10.3109/17453677608989711.
A new porous ceramic material was tested for possible use as a bone substitute in regions exposed mainly to compressive forces. The porous ceramics were implanted into the medial condyle of the tibia of four sheep and left in position for 3 months. The operated tibia was then removed and sections were made of the implants. The sections were studied by transmitted light microscopy, microradiography and scanning electron microscopy. There was no apparent loss of function of the operated leg and the implants were found to be bound to the adjacent bone by ingrowth of bony tissue, in some regions to a depth of 2-3 mm. It is concluded that the properties of the porous ceramic implants justify a clinical trial, provided that the results of long-term animal experiments are equally satisfactory.
一种新型多孔陶瓷材料被测试，看其是否有可能用作主要承受压缩力区域的骨替代物。将多孔陶瓷植入四只绵羊胫骨的内侧髁，并放置3个月。然后取出手术的胫骨，对植入物进行切片。通过透射光显微镜、微放射照相术和扫描电子显微镜对切片进行研究。手术腿没有明显的功能丧失，并且发现植入物通过骨组织向内生长与相邻骨结合，在某些区域向内生长深度达2-3毫米。得出的结论是，多孔陶瓷植入物的特性证明进行临床试验是合理的，前提是长期动物实验的结果同样令人满意。
