Scoazec J-Y
Service Central d'Anatomie et Cytologie Pathologiques, INSERM U45, Hôspital Edouard Herriot, Lyon, France.
Gut. 2003 Jun;52 Suppl 4(Suppl 4):iv1-6. doi: 10.1136/gut.52.suppl_4.iv1.
Morphological sciences have recently experienced a significant technological breakthrough that offers new opportunities for cell and tissue imaging in situ but also raises new challenges to pathologists, who must adapt to a rapidly evolving environment. New partners, such as cell and molecular biologists, have provided pathologists with highly powerful tools for cell and subcellular imaging. They include: (a) the adaptation of techniques derived from molecular biology and cytogenetics, (b) the development of new microscopic tools, such as confocal microscopy, and (c) the emergence of new preparative techniques, such as microdissection or tissue arrays. However, recent technological progresses in various fields, from endoscopy to genomics, also raise new challenges to pathologists. Pathologists must therefore be prepared to redefine their area of expertise: this will be achieved through a continuous collaboration with all the partners involved in cell and tissue imaging and analysis but also by emphasising the importance of the informations provided by cell and tissue imaging in situ.
形态科学最近经历了重大的技术突破，这为原位细胞和组织成像提供了新机遇，但也给病理学家带来了新挑战，他们必须适应快速变化的环境。细胞和分子生物学家等新伙伴为病理学家提供了用于细胞和亚细胞成像的强大工具。这些工具包括：（a）源自分子生物学和细胞遗传学技术的应用，（b）新型显微镜工具（如共聚焦显微镜）的开发，以及（c）新制备技术（如显微切割或组织芯片）的出现。然而，从内窥镜检查到基因组学等各个领域的最新技术进展也给病理学家带来了新挑战。因此，病理学家必须准备好重新定义其专业领域：这将通过与参与细胞和组织成像及分析的所有伙伴持续合作来实现，同时也要强调原位细胞和组织成像所提供信息的重要性。
