Casey Mary B, Lohse Christine M, Lloyd Ricardo V
Department of Laboratory Medicine and Pathology, Mayo Clinic and Mayo Foundation, Rochester, MN, USA.
Endocr Pathol. 2003 Spring;14(1):55-60. doi: 10.1385/ep:14:1:55.
The histopathology of papillary thyroid hyperplasia and papillary thyroid carcinoma is similar enough to cause a diagnostic dilemma in a few cases. Both lesions may have papillary fronds with fibrovascular cores, nuclear crowding, and nuclear anisocytosis. Formalin- fixed paraffin-embedded tissues from 30 randomly selected patients with papillary thyroid hyperplasia and an equal number from patients with papillary thyroid carcinoma were analyzed for expression of cytokeratin 19 (CK19), galectin-3, and HBME-1. Cases of papillary thyroid carcinoma had moderate to strong CK19, galectin-3, and HBME-1 reactivity although both CK19 and galectin-3 showed positive staining in a significant number of nonneoplastic thyroid cases. HBME-1 was uncommon in the nonneoplastic cases. These results indicate that HBME-1 may be useful in helping to distinguish papillary thyroid carcinoma from hyperplasia in diagnostically difficult cases.
甲状腺乳头状增生和甲状腺乳头状癌的组织病理学非常相似，以至于在少数病例中会造成诊断上的两难困境。这两种病变都可能有带有纤维血管轴心的乳头样结构、核拥挤和核大小不等。对随机选取的30例甲状腺乳头状增生患者以及数量相同的甲状腺乳头状癌患者的福尔马林固定石蜡包埋组织进行细胞角蛋白19（CK19）、半乳糖凝集素-3和HBME-1表达分析。甲状腺乳头状癌病例有中度至强的CK19、半乳糖凝集素-3和HBME-1反应性，尽管CK19和半乳糖凝集素-3在大量非肿瘤性甲状腺病例中也呈阳性染色。HBME-1在非肿瘤性病例中不常见。这些结果表明，在诊断困难的病例中，HBME-1可能有助于区分甲状腺乳头状癌和增生。
