Nelson Sarah J
Magnetic Resonance Science Center, University of California San Francisco, San Francisco, California 94143-1290, USA.
Mol Cancer Ther. 2003 May;2(5):497-507.
Magnetic resonance spectroscopy (MRS) is becoming more widely available for clinical applications and is able to provide information about the metabolic properties of regions of normal and abnormal tissue morphology. A critical question for the clinical management of patients with brain tumors is whether multivoxel MRS is able to add new information to the high-quality anatomical data provided by conventional MR imaging techniques and whether this information is relevant for the diagnosis and clinical management of such patients. In this article, the state of the art for acquiring and analyzing multivoxel MRS data is reviewed and placed in context relative to imaging findings for metastatic and primary brain tumors. The MRS data are seen to provide unique information that when combined with high-quality anatomical MR images has implications for defining tumor type and grade, directing biopsy or surgical resection, planning focal radiation or biological therapies, and understanding the mechanisms of success and failure of new treatments.
磁共振波谱（MRS）在临床应用中越来越普及，能够提供有关正常和异常组织形态区域代谢特性的信息。对于脑肿瘤患者的临床管理而言，一个关键问题是多体素MRS是否能够为传统磁共振成像技术提供的高质量解剖数据增添新信息，以及该信息是否与这类患者的诊断和临床管理相关。在本文中，将对获取和分析多体素MRS数据的现有技术水平进行综述，并结合转移性和原发性脑肿瘤的影像学表现进行阐述。MRS数据被认为可提供独特信息，当与高质量解剖磁共振图像相结合时，对于确定肿瘤类型和分级、指导活检或手术切除、规划局部放疗或生物治疗以及理解新治疗方法的成败机制具有重要意义。
