Joussen A M, Fauser S, Krohne T U, Lemmen K-D, Lang G E, Kirchhof B
Abteilung für Netzhaut- und Glaskörperchirurgie des Zentrums für Augenheilkunde und Zentrum für Molekulare Medizin (ZMMK) Universität zu Köln, Cologne.
Ophthalmologe. 2003 May;100(5):363-70. doi: 10.1007/s00347-003-0800-8.
Diabetic retinopathy is the most common chronic microvascular complication associated with diabetes mellitus. The development of diabetic retinopathy is a consequence of metabolic dysregulation. Hyperglycemia is a critical factor which is involved in basement membrane thickening, loss of pericytes and endothelial cells, and retinal capillary nonperfusion. We review the molecular basis of diabetic retinopathy and maculopathy and elaborate the role of growth factors and cytokines in the development of diabetic vascular alterations, their specific influence on the cellular interaction between retinal endothelial cells and pericytes, and the role of intravascular blood components.
糖尿病视网膜病变是与糖尿病相关的最常见慢性微血管并发症。糖尿病视网膜病变的发生是代谢失调的结果。高血糖是一个关键因素，它参与基底膜增厚、周细胞和内皮细胞丢失以及视网膜毛细血管无灌注。我们综述了糖尿病视网膜病变和黄斑病变的分子基础，并阐述了生长因子和细胞因子在糖尿病血管改变发生中的作用、它们对视网膜内皮细胞与周细胞之间细胞相互作用的特定影响以及血管内血液成分的作用。
