[光动力疗法：扩展适应症]

[Photodynamic therapy: extended indication].

作者信息

Müller-Velten R, Michels St, Schmidt-Erfurth U, Laqua H

机构信息

Universitätsaugenklinik Lübeck.

出版信息

Ophthalmologe. 2003 May;100(5):384-90. doi: 10.1007/s00347-002-0723-9.

DOI:10.1007/s00347-002-0723-9

PMID:12748804

Abstract

OBJECTIVE

Evaluation of efficacy of photodynamic therapy (PDT) for classic choroidal neovascularization (CNV) beyond the common indication.

METHODS

A group of 256 patients was treated with photodynamic therapy from January to December 2000. Ten of these patients had a predominantly classic CNV due to angioid streaks (5), parafoveal telangiectasia (2), or chorioretinitis (3). In two patients an idiopathic origin of the CNV was presumed. Another 21 patients showed a juxtafoveal classic membrane (12) or a recurrence after laser photocoagulation (9). Visual acuity was evaluated, also in correlation to age and CNV size. Continuous follow-up of CNV and leakage size was performed with fluorescein angiography.

RESULTS

Overall 85% of the patients showed visual stabilization or improvement during an average observation period of 10.5 months. A correlation was found between age and visual improvement favoring younger patients; however, no correlation was found between visual improvement and CNV size. CNV and leakage size decreased moderately over the 9-month follow-up from 1.81/3.45 mm(2) to 1.61/2.60 mm(2).

CONCLUSION

PDT shows efficacy for classic choroidal neovascularization beyond the common indication.

摘要

目的

评估光动力疗法（PDT）治疗超出常见适应证的典型脉络膜新生血管（CNV）的疗效。

方法

2000年1月至12月，一组256例患者接受了光动力疗法治疗。其中10例患者主要患有典型CNV，病因分别为血管样条纹（5例）、黄斑旁毛细血管扩张（2例）或脉络膜视网膜炎（3例）。另外2例患者推测CNV为特发性起源。另有21例患者表现为黄斑旁典型膜（12例）或激光光凝术后复发（9例）。评估了视力，并将其与年龄和CNV大小进行了关联分析。通过荧光素血管造影对CNV和渗漏大小进行持续随访。