Anastasiadis P G, Kotini A, Anninos P, Adamopoulos A, Sigalas J, Koutlaki N
Department of Obstetrics and Gynaecology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
Prenat Diagn. 2003 May;23(5):405-9. doi: 10.1002/pd.612.
We studied how chaotic and periodic heart rate dynamics differ between normal fetuses (n = 19) and intrauterine growth restricted fetuses (n = 11) at 34 to 37 weeks of gestation. We quantified the chaotic dynamics of each heart rate time series obtained by fetal magnetocardiography (FMCG) using correlation dimension.
The FMCG was recorded digitally by a single-channel biomagnetometer in an electrically shielded room of low magnetic noise. The position of the fetal heart was determined using ultrasonography.
The correlation dimension was significantly lower in IUGR than in normal fetuses (p < 0.001, t-test). The periodic dynamics were also obtained by FMCG and measured by power spectrum. The low-frequency components and therefore the periodicity of the low-frequency range were significantly higher in IUGR than in normal fetuses (p < 0.001, t-test).
The analysis of FMCG recordings may offer important perspectives to understand significant features of the heart function of the fetuses. This technique improves the recognition of IUGR fetuses over healthy ones and may help improve perinatal morbidity and mortality.
我们研究了妊娠34至37周时，正常胎儿（n = 19）和宫内生长受限胎儿（n = 11）的心率动态的混沌和周期性差异。我们使用关联维数对通过胎儿心磁图（FMCG）获得的每个心率时间序列的混沌动态进行了量化。
在低磁噪声的电屏蔽室内，使用单通道生物磁强计对FMCG进行数字记录。使用超声检查确定胎儿心脏的位置。
宫内生长受限胎儿的关联维数显著低于正常胎儿（p < 0.001，t检验）。FMCG还获得了周期性动态，并通过功率谱进行测量。宫内生长受限胎儿的低频成分以及低频范围的周期性显著高于正常胎儿（p < 0.001，t检验）。
FMCG记录分析可能为理解胎儿心脏功能的重要特征提供重要视角。该技术提高了对宫内生长受限胎儿相对于健康胎儿的识别能力，并可能有助于改善围产期发病率和死亡率。
