Department of Obstetrics and Gynaecology, Monash University, 252 Clayton Road, Clayton, Victoria, 3168, Australia.
Biorithm Pte Ltd, 81 Ayer Rajah Crescent 03-53, Singapore, 139967, Singapore.
BMC Pregnancy Childbirth. 2019 Jul 5;19(1):230. doi: 10.1186/s12884-019-2357-9.
Non-invasive electrophysiological assessment (NIEA) is an evolving area in fetal surveillance and is attracting increasing research interest. There is however, limited data outlining its utility in evaluating intra uterine growth restriction (IUGR). The objective of this study was to carry out a systematic review to outline the utility of NIEA parameters in evaluating IUGR.
A systematic review of peer reviewed literature was performed, searching PUBMED, Ovid MEDLINE and EMBASE. The outcomes of interest included NIEA parameters [P wave duration, PR interval, QRS duration, QT interval, T/QRS ratio, short term variability (STV) and long term variability (LTV)] and a descriptive summary of relevant studies as well.
Sixteen studies were identified as suitable for inclusion. The utility of NIEA parameters were investigated in tabular form. In particular, QRS and QT duration, T/QRS ratio, STV and PRSA analysis displayed utility and merit further consideration in evaluating for IUGR. Issues identified in the review were in relation to variances in definition of IUGR, small sample sizes and the lack of technological consistency across studies.
NIEA shows promise as an adjunct surveillance tool in fetal diagnostics for IUGR. Larger prospective studies should be directed towards establishing reliable parameters with a focus on uniformity of IUGR definition, technological consistency and the individualisation of NIEA parameters.
非侵入性电生理评估（NIEA）是胎儿监测领域的一个新兴领域，越来越受到研究关注。然而，关于其在评估宫内生长受限（IUGR）中的应用，数据有限。本研究的目的是进行系统评价，概述 NIEA 参数在评估 IUGR 中的应用。
对同行评审文献进行系统评价，检索 PUBMED、Ovid MEDLINE 和 EMBASE。感兴趣的结局包括 NIEA 参数[P 波持续时间、PR 间期、QRS 持续时间、QT 间期、T/QRS 比值、短期变异性（STV）和长期变异性（LTV）]以及相关研究的描述性总结。
确定了 16 项适合纳入的研究。以表格形式研究了 NIEA 参数的应用。特别是 QRS 和 QT 持续时间、T/QRS 比值、STV 和 PRSA 分析显示出在评估 IUGR 方面的应用价值和进一步考虑的价值。审查中发现的问题与 IUGR 的定义差异、样本量小以及研究之间缺乏技术一致性有关。
NIEA 作为胎儿诊断中 IUGR 的辅助监测工具具有一定前景。应开展更大规模的前瞻性研究，以建立可靠的参数，重点关注 IUGR 定义的一致性、技术一致性和 NIEA 参数的个体化。
