Arima T, Miyamoto-Sudo C, Hiroata M, Tanigawa T, Tsuboi S
Acta Med Okayama. 1975 Jun;29(3):199-208.
An eleventh case of heavy (Hgamma1) chain disease (Yok), surviving for more than 10 years and still living showed clinical and pathological findings similar to cases described in the past. The patient was given only glucocorticosteroids, ACTH, antibiotics and gamma globulin, as specific drugs. Precipitation arcs besides the major ones formed by albumin and Fc fragment were disclosed by immunoelectrophoresis. The existence of these minor components were confirmed with antigen-antibody crossed electrophoresis and Sephadex G-200 gel filtration. They did not form precipitation arcs with the other antigens available and they appeared in the same fractions of IgG on gel filtration suggesting their having higher molecular weight than the major ones. In addition to these findings, the clinical course of the patient is described.
第11例重链（Hγ1）病（Yok型）患者存活超过10年，目前仍在世，其临床和病理表现与既往报道的病例相似。作为特效药物，该患者仅接受了糖皮质激素、促肾上腺皮质激素、抗生素和γ球蛋白治疗。免疫电泳显示，除了由白蛋白和Fc片段形成的主要沉淀弧外，还出现了其他沉淀弧。通过抗原-抗体交叉电泳和Sephadex G-200凝胶过滤证实了这些次要成分的存在。它们与其他可用抗原不形成沉淀弧，并且在凝胶过滤中出现在与IgG相同的组分中，表明它们的分子量比主要成分更高。除这些发现外，还描述了该患者的临床病程。
