呼吸窘迫综合征早产儿的血浆中性粒细胞脂质运载蛋白、弹性蛋白酶-α1-抗胰蛋白酶复合物及中性粒细胞蛋白酶4

Plasma neutrophil lipocalin, elastase-alpha1-antitrypsin complex and neutrophil protease 4 in preterm infants with respiratory distress syndrome.

作者信息

Sveger T, Ohlsson K, Mörse H, Polberger S, Laurin S

机构信息

Department of Paediatrics, University of Lund, University Hospital, Malmö, Sweden.

出版信息

Scand J Clin Lab Invest. 2003;63(2):89-92.

PMID:12751689

Abstract

Respiratory distress syndrome (RDS) and chronic lung disease of prematurity (CLD) are associated with inflammation of the airways and interstitial tissue of the lung. It is hypothesized that RDS severity and the risk of developing CLD may be correlated with neutrophil gelatinase-associated lipocalin (NGAL), a marker of leucocyte activity, human elastase-alpha1-antitrypsin complex (HEAT) or free and complexed neutrophil protease 4 (NP4), markers of proteolytic enzyme secretion from granulocytes. Thirty-three preterm infants with RDS were enrolled in the study and plasma sampled between 3 and 14 days of life. NGAL, HEAT and NP4 concentrations varied widely in infants with RDS. Significant correlations between subsequent development of CLD and plasma concentrations of HEAT and NP4, respectively, were found on days 3-4 of life, p=0.006 and p=0.02, respectively.

摘要

呼吸窘迫综合征（RDS）和早产儿慢性肺病（CLD）与气道炎症和肺间质组织炎症相关。据推测，RDS的严重程度和发生CLD的风险可能与中性粒细胞明胶酶相关脂质运载蛋白（NGAL，一种白细胞活性标志物）、人弹性蛋白酶-α1抗胰蛋白酶复合物（HEAT）或游离及复合形式的中性粒细胞蛋白酶4（NP4，粒细胞分泌的蛋白水解酶标志物）相关。33例患有RDS的早产儿被纳入该研究，并在出生后3至14天采集血浆样本。患有RDS的婴儿中，NGAL、HEAT和NP4浓度差异很大。在出生后第3至4天，分别发现CLD的后续发展与血浆HEAT和NP4浓度之间存在显著相关性，p值分别为0.006和0.02。