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留存率重要吗?治疗时长与药物使用改善情况。

Does retention matter? Treatment duration and improvement in drug use.

作者信息

Zhang Zhiwei, Friedmann Peter D, Gerstein Dean R

机构信息

NORC at the University of Chicago, Washington, DC 20036, USA.

出版信息

Addiction. 2003 May;98(5):673-84. doi: 10.1046/j.1360-0443.2003.00354.x.

DOI:10.1046/j.1360-0443.2003.00354.x
PMID:12751985
Abstract

AIM

This study examines whether there is a minimum threshold, continuous or non-linear relationship between the duration of addiction treatment and improvements in drug use.

DESIGN

Longitudinal cohort study of 62 drug treatment units and 4005 clients in the US National Treatment Improvement Evaluation Study, fielded from 1993 to 1995.

SUBJECTS

Baseline and 1-year follow-up interviews with clients in methadone maintenance, out-patient non-methadone, short-term residential and long-term residential treatment programs.

MEASURES

Improvement in drug use is the difference between the client-reported peak frequency of drug use (in days per month) in the year prior to the baseline interview minus the peak frequency in the year after discharge. Primary drug, and overall use of the major illicit drugs (heroin, cocaine powder, crack cocaine, and marijuana) are considered separately.

RESULTS

Controlling for multiple factors, treatment duration had a positive linear relationship with primary drug use improvement among methadone clients and an inverted-U-shaped relationship with overall and primary drug use improvements among out-patient and long-term residential clients. Improvement with longer duration is greatest for long-term residential clients.

CONCLUSIONS

Contrary to previous arguments for a sharp retention threshold for onset of treatment effects, we find smooth curves relating treatment duration to drug use improvements in methadone maintenance, out-patient non-methadone and long-term residential modalities. These relationships are effectively linear for durations typically observed in single treatment episodes, but unusually long retention in out-patient non-methadone and long-term residential units appear steadily less predictive of improvement.

摘要

目的

本研究探讨成瘾治疗时长与药物使用改善之间是否存在最低阈值、连续或非线性关系。

设计

在美国国家治疗改善评估研究中,对62个药物治疗单位和4005名患者进行的纵向队列研究,研究时间为1993年至1995年。

研究对象

对接受美沙酮维持治疗、门诊非美沙酮治疗、短期住院治疗和长期住院治疗项目的患者进行基线和1年随访访谈。

测量方法

药物使用的改善是指患者报告的基线访谈前一年药物使用的高峰频率(每月天数)与出院后一年的高峰频率之差。分别考虑主要药物以及主要非法药物(海洛因、可卡因粉、快克可卡因和大麻)的总体使用情况。

结果

在控制多个因素后,治疗时长与美沙酮治疗患者的主要药物使用改善呈正线性关系,与门诊和长期住院患者的总体及主要药物使用改善呈倒U形关系。长期住院患者治疗时间越长,改善程度越大。

结论

与之前关于治疗效果开始的明显保留阈值的观点相反,我们发现在美沙酮维持治疗、门诊非美沙酮治疗和长期住院治疗模式中,治疗时长与药物使用改善之间存在平滑曲线关系。对于单次治疗中通常观察到的时长,这些关系实际上是线性的,但在门诊非美沙酮治疗和长期住院治疗单位中异常长的保留时间对改善的预测性似乎越来越低。

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