产前暴露于流感是成人精神分裂症的一个风险因素。
Prenatal exposure to influenza as a risk factor for adult schizophrenia.
作者信息
Limosin F, Rouillon F, Payan C, Cohen J-M, Strub N
机构信息
Service de Psychiatrie, Hôpital Albert Chenevier, Créteil Cedex, France.
出版信息
Acta Psychiatr Scand. 2003 May;107(5):331-5. doi: 10.1034/j.1600-0447.2003.00052.x.
OBJECTIVE
Several, but not all epidemiological studies, have demonstrated a positive correlation between exposure to the virus during the second trimester of pregnancy and an increased risk to the infants for subsequently developing schizophrenia. The present study is the first be designed in France to examine the risk of gestational exposure to the influenza virus and subsequent development of schizophrenia.
METHOD
A total of 974 adults with schizophrenia born between 1949 and 1981 were compared for risk of exposure to influenza with their non-schizophrenic siblings and with matched control patients.
RESULTS
Significantly more schizophrenic subjects than controls (both groups) had been exposed to the influenza virus during the fifth month of pregnancy (OR=2.24, CI: 1.49-3.35, and OR=1.61, CI: 1.04-2.49).
CONCLUSION
These results suggest that influenza infection during pregnancy is a neurodevelopmental risk factor for schizophrenia in adult life.
目的
一些（但并非全部）流行病学研究表明，孕期第二个三月期接触该病毒与婴儿日后患精神分裂症风险增加之间存在正相关。本研究是法国首个旨在研究孕期接触流感病毒的风险以及随后患精神分裂症情况的研究。
方法
对1949年至1981年出生的974名成年精神分裂症患者，就其接触流感的风险与其非精神分裂症的兄弟姐妹以及匹配的对照患者进行比较。
结果
与对照组（两组）相比，明显有更多的精神分裂症患者在孕期第五个月接触过流感病毒（比值比=2.24，可信区间：1.49 - 3.35；比值比=1.61，可信区间：1.04 - 2.49）。
结论
这些结果表明，孕期流感感染是成年后患精神分裂症的一个神经发育风险因素。
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