Selten J P, Slaets J P
Rosenburg Psychiatric Hospital, The Hague, The Netherlands.
Br J Psychiatry. 1994 May;164(5):674-6. doi: 10.1192/bjp.164.5.674.
We tested the hypothesis that second-trimester exposure to influenza is a risk factor for schizophrenia in the child. The dates of birth of Dutch schizophrenic in-patients were examined for any effect of the 1957 A2 influenza epidemic. Individuals who were in their second trimester of foetal life at the peak of the epidemic were at no greater risk of developing schizophrenia than controls. As the present study has a larger sample size than all previous European studies, and is supported by a large study in the USA, it provides strong evidence against the hypothesis that second-trimester exposure to influenza is a risk factor for schizophrenia.
孕期中期暴露于流感是儿童患精神分裂症的一个风险因素。我们研究了荷兰精神分裂症住院患者的出生日期，以考察1957年A2型流感大流行的任何影响。在流感大流行高峰期处于胎儿期第二个三月期的个体，患精神分裂症的风险并不高于对照组。由于本研究的样本量比之前所有欧洲研究都大，且得到了美国一项大型研究的支持，它为反对孕期中期暴露于流感是精神分裂症风险因素这一假设提供了有力证据。
