Wu Jason K, Siller Greg, Whitehead Kevin
Department of Dermatology, Princess Alexandra Hospital, Queensland, Australia.
Australas J Dermatol. 2003 May;44(2):123-5. doi: 10.1046/j.1440-0960.2003.00658.x.
We report the successful use of topical imiquimod 5% cream for extensive multifocal, recurrent (post cryotherapy), biopsy-proven Bowen's disease of the nose. Treatment was applied on a once-a-day regimen, and a total of 32 applications over 9 weeks were used. A florid local skin reaction occurred early in the treatment, necessitating a rest period and decreasing the frequency of application. The Bowen's disease was coexistent with a multifocal superficial basal cell carcinoma (BCC) that had a partial response. Persistent BCC at 4 weeks post treatment was surgically excised. This tumour showed an unusual histological picture, with normal epidermis overlying residual BCC in the papillary dermis. The Bowen's disease remains clinically clear at 12-months follow up.
我们报告了5%咪喹莫特乳膏成功用于治疗广泛多灶性、复发性（冷冻治疗后）、经活检证实的鼻部鲍恩病。治疗采用每日一次的方案，9周内共涂抹32次。治疗早期出现了明显的局部皮肤反应，需要休息一段时间并减少涂抹频率。鲍恩病与多灶性浅表基底细胞癌（BCC）共存，后者有部分反应。治疗后4周持续存在的BCC通过手术切除。该肿瘤显示出不寻常的组织学图像，乳头层真皮中残留的BCC上方覆盖着正常表皮。在12个月的随访中，鲍恩病在临床上仍然清晰。
